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Idiopathic thrombocytopenic purpura (ITP)

Definition:
Idiopathic thrombocytopenic purpura is a bleeding disorder characterized by too few platelets in the blood. This is because platelets are being destroyed by the immune system. Idiopathic means the exact cause of the disease is unknown.

Alternative Names:
Immune thrombocytopenic purpura; ITP

Causes, incidence, and risk factors:

The disease occurs when immune system cells, called lymphocytes, produce antibodies against platelets. Platelets are necessary for normal blood clotting. They clump together to plug small holes in damaged vessels.

The presence of antibodies on platelets leads to their destruction in the spleen. A characteristic skin rash, easy bruising, abnormal menstrual bleeding, or sudden and severe loss of blood from the gastrointestinal tract may occur.

Usually, no other abnormal findings are present. In children, the disease is sometimes preceded by a viral infection and usually runs its course without treatment. In adults, it is more often a chronic (long-term) disease and can follow a viral infection, certain drugs, pregnancy, or other immune disorders.

ITP affects women more frequently than men, and is more common in children than adults. There is no sex difference in children.



Review Date: 5/1/2003
Reviewed By: Ezra E. W. Cohen, M.D., Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL. Review provided by VeriMed Healthcare Network.

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