The objectives of therapy are to control the infection and relieve symptoms. Antiviral medications that may be used include ganciclovir (Cytovene) or foscarnet (Foscavir). Treatment is given intravenously and sometimes orally for several weeks.

In some cases, therapy may be prolonged. CMV hyperimmune globulin may be used in cases of severe refractory infection. Antidiarrheal medications and analgesics are used for the relief of symptoms.

Nutritional supplements or intravenous nutrition to combat wasting may be indicated.

Individuals with normal immune systems typically have a self-limited infection, with resolution of symptoms without treatment. Those who have suppressed immune systems have more severe symptoms due to the infection. The outcome depends upon the severity of the immunodeficiency and the severity of the infection.

People with AIDS may have a worse outcome than those with a different immunodeficiency. CMV infection typically is a systemic disease, even if patients only have GI symptoms. Therefore, overall outcome depends on the response to systemic therapy with antiviral drugs.

Low white blood cell count may occur with use of ganciclovir. Kidney impairment may occur with the use of foscarnet.

Call for an appointment with your health care provider if symptoms develop that are suggestive of CMV gastroenteritis.