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Hyperimmunoglobulin E syndrome |
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| Alternative Names: | Job syndrome; Hyper IgE syndrome
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| Signs and tests: | - keratoconjunctivitis
- osteomyelitis
- kyphoscoliosis
- lung abscesses on chest X-ray
- recurrent sinus infection
Tests to confirm a diagnosis: - Quantitative immunoglobulins reveal high serum IgE levels
- marked eosinophilia by CBC with differential
- defective neutrophil and monocyte chemotactic studies (though not in all cases)
- absent delayed hypersensitivity (DCNB, candidal)
Other tests may be done in response to infections:
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Review Date: 12/1/2001
Reviewed By: Frederic F. Little, M.D., Department of Allergy and Pulmonary/Critical Care Medicine, Boston University School of Medicine, Boston, MA. Review provided by VeriMed Healthcare Network.
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