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| Alternative Names: | Hyperthermia - malignant; Hyperpyrexia - malignant
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| Symptoms: | - Rapid rise in temperature following administration of anesthesia
- Muscle rigidity and stiffness following administration of anesthesia
- Dark brown coloration to urine
- Muscle ache without obvious exercise to explain sore muscles
- Family history of malignant hyperthermia or unexplained death during anesthesia
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| Signs and tests: | - Blood chemistry (see chem-20) shows increased blood levels of creatine phosphokinase (CPK), potassium, uric acid, phosphate.
- Myoglobin in the urine is elevated.
- Muscle biopsy using an in vitro contracture test may show abnormal results in response to certain drugs such as caffeine and halothane (an anesthetic).
- Muscle biopsy may show abnormal muscle, such as central cores, in some types.
- Genetic testing such as ryanodine receptor (RYR1) may show gene abnormalities.
- Phosphorus magnetic resonance spectroscopy, a research test, may show abnormal muscle function.
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Review Date: 8/19/2003
Reviewed By: Douglas R. Stewart, M.D., Division of Medical Genetics, Hospital of the University of Pennsylvania, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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