Brain herniation occurs when pressure inside the skull (intracranial pressure) increases and displaces brain tissues. This is commonly the result of brain swelling from a head injury. It can also be caused by space-occupying lesions such as primary brain tumor, metastatic brain tumor, and hemorrhages or strokes that produce swelling within the brain. Brain herniation itself often causes massive stroke, resulting from poor blood supply to some areas of brain and compression of vital structures that compromise cardiovascular and respiratory centers. This can rapidly lead to death or brain death. Brain herniations are the most common secondary effect of expanding intracranial masses.
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