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Ehlers-Danlos syndrome

Definition:
Ehlers-Danos syndrome is a group of inherited disorders characterized by excessive looseness (laxity) of the joints, hyperelastic skin that is fragile and bruises easily, and/or easily damaged blood vessels. The syndrome sometimes involves rupture of internal organs.

Causes, incidence, and risk factors:

Ehlers-Danlos syndrome (EDS) can occur in different forms -- involving vessels, skin, and/or joints -- with a variety of different genetic defects as their cause.

Different forms of EDS have different modes of inheritance. Family history is a risk factor in some cases.



Review Date: 2/5/2003
Reviewed By: Douglas R. Stewart, M.D., Division of Medical Genetics, Hospital of the University of Pennsylvania, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

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